Publications

 

  • Shin HR, Citron YR, Wang L, Tribouillard L, Goul CS, Stipp R, Sugasawa Y, Jain A, Samson N, Lim CY, Davis OB, Castaneda-Carpio D, Qian M, Nomura DK, Perera RM, Park E, Covey DF, Laplante M, Evers AS, Zoncu R.* Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1. Science:2022, 377 (6612), 1290–1298.

  • Shrestha MM, Lim CY, Bi X, Robinson RC, Han W.* Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts. Frontiers in Endocrinology: 2021, 12, 653557.

  • Davis OB, Shin HR, Lim CY, Wu EY, Kukurugya M, Maher CF, Perera RM, Ordonez MP, Zoncu R.* NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C. Developmental Cell: 2021, 56 (3), 260–276.

  • Lim CY, Davis O, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R.* ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signaling in Niemann-Pick type C. Nature Cell Biology: 2019, 21 (10), 1206–1218.

  • Lim CY, Zoncu R.* The lysosome as a command and control center for cellular metabolism. Journal of Cell Biology: 2016, 214 (6), 653–664.

  • Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R.* Structural mechanisms of a Rag GTPase activation checkpoint by the lysosomal folliculin complex. Science: 2019, 366 (6468), 971–977. 

  • Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK.* A unified approach to targeting the lysosome's degradative and growth signaling roles. Cancer Discovery: 2017, 7 (11), 1266–1283.

  • Lim CY, Bi XZ, Wu D, Kim JB, Gunning PW, Hong W, Han W.* Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling. Nature Communications: 2015, 6 (1), 1–15.

  • Lim CY, Han W.* Tropomodulin3 as the link between insulin-activated Akt2 and cortical actin remodeling in preparation of GLUT4 exocytosis. Bioarchitecture: 2014, 4 (6), 210–214.

  • Yang W, Thein S, Lim CY, Ericksen RE, Sugii S, Xu F, Robinson RC, Kim JB, Han W.* Arp2/3 complex regulates adipogenesis by controlling cortical actin remodeling. Biochemical Journal: 2014, 464 (2), 179–192.

  • Lim CY, Hong W, Han W.* Adiponectin is released via a unique regulated exocytosis pathway from a pre-formed pool of vesicles upon insulin stimulation. Biochemical Journal: 2015, 471 (3), 381–389.

  • Wang Y, Ali Y, Lim CY, Hong W, Pang Z, Han W.* Insulin-stimulated leptin secretion requires calcium and PI3K-Akt activation. Biochemical Journal: 2014, 458 (3), 491–498.

  • Kim JI, Huh JY, Sohn JH, Choe SS, Lee YS, Lim CY, Jo A, Park SB, Han W, Kim JB.* Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Molecular and Cellular Biology: 2015, 35(10), 1686–1699.

  • Liu Z#, Lim CY#, Su MY#, Soh SL, Shui G, Wenk MR, Grove K, Radda GK, Han W, Xiao X.* Neonatal Overnutrition in the Mice Exacerbates High Fat Diet Induced Metabolic Perturbations. Journal of Endocrinology: 2013, 219 (2), 131–143.

  • Kostromina E, Gustavsson N, Wang X, Lim CY, Radda GK, Li C, Han W.* Glucose Intolerance and Impaired Insulin Secretion in Pancreas-Specific Signal Transducer and Activator of Transcription-3 Knockout Mice Are Associated with Microvascular Alterations in the Pancreas. Endocrinology: 2010, 151 (5), 2050–2059.

  • Yang G, Lim CY, Li C, Xiao X, Radda GK, Li C, Cao X, Han W.* FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1. Journal of Biological Chemistry: 2009, 284 (6), 3719–3727.

  • Ang BK, Lim CY, Koh SS, Sivakumar N, Taib S, Lim KB, Ahmed S, Rajagopal G, Ong SH.* ArhGAP9, a novel MAP kinase docking protein, inhibits Erk and p38 activation through WW domain binding. Journal of Molecular Signaling: 2007, 2 (1),1.